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Managing adolescent illness: Make it a game!

Childhood illnesses can be difficult to handle for both parents and children. Here are a few ways researchers and software developers have teamed up to make things a little bit easier . . . and a little more fun.

Re-Mission

Re-MissionRe-mission is a video game that educates adolescent cancer patients about their disease. Players pilot the character Roxxi, a nanobot, through bodies of fictional cancer patients, destroying cancer cells, battling bacterial infections, and managing cancer- and treatment-related side effects.

A 2008 study in Pediatrics1 showed that kids undergoing cancer therapy who played the game

  • followed their treatment plan more closely,
  • possessed considerably greater knowledge of their disease,
  • and demonstrated greater self-sufficiency throughout treatment than children who did not play Re-Mission.

didgetDidget

Bayer Healthcare recently teamed up with Nintendo to produce Didget, a glucose-monitoring game that rewards children with “points” for monitoring their blood glucose levels and keeping the levels within a personalized target range. The kids can then use their earned points to unlock new game levels and buy items in the game.

Read more about pioneering research in gaming and child healthcare.

1 Kato, P., Cole, S., Bradlyn, A., & Pollock, B. (2008). A Video Game Improves Behavioral Outcomes in Adolescents and Young Adults With Cancer: A Randomized Trial PEDIATRICS, 122 (2) DOI: 10.1542/peds.2007-3134

Birth Control: Desire on Schedule

Birth ControlIf she wants to attract a man, studies have shown that a woman is better off not wearing perfume. This is because humans, like animals, use scent to identify and attract mates—particularly mates who are genetically dissimilar.

Research suggests that the major histocompatibility complex (MHC) genes are one set of genes that women “sniff out” to determine mate compatibility. Studies published as long ago as 19951 show that women prefer men whose MHC genes differ from their own. This preference is most likely hard-wired by evolution, since children of genetically diverse parents have a better chance of surviving than, say, children of first cousins.

However, another study published in Proc. R. Soc. B, 20082 demonstrates that women taking oral contraceptives start to prefer men with similar MHC genes. One hypothesis suggests that the pill causes a hormonal shift mimicking pregnancy. During pregnancy, women are drawn toward nurturing relatives who, consequently, will have a similar genetic makeup. Thus, women on the pill prefer genetically similar men due to this “false pregnancy” state that induces them to seek caregivers and protectors, rather than ideal mates.

This shift in mate preference can have severe consequences. Not only are MHC-similar couples more likely to bear children with weaker immune systems, but they’re also more likely to break up. A study published in  Psychological Science, 20073 found that women are more likely to be unfaithful (due to sexual dissatisfaction) when paired with MHC-similar men than MHC-dissimilar men.

Still skeptical? Read more about how mate preference can be altered in Trends in Ecology & Evolution, March 2010.4 The findings are at least worth considering if you’re still trying to find your “perfect match” . . . or even preserve a relationship with the match you’ve found.

1 Wedekind C, Seebeck T, Bettens F, & Paepke AJ (1995). MHC-dependent mate preferences in humans. Proceedings. Biological sciences / The Royal Society, 260 (1359), 245-9 PMID: 7630893

2 Roberts, S., Gosling, L., Carter, V., & Petrie, M. (2008). MHC-correlated odour preferences in humans and the use of oral contraceptives Proceedings of the Royal Society B: Biological Sciences, 275 (1652), 2715-2722 DOI: 10.1098/rspb.2008.0825

3 Garver-Apgar, C., Gangestad, S., Thornhill, R., Miller, R., & Olp, J. (2006). Major Histocompatibility Complex Alleles, Sexual Responsivity, and Unfaithfulness in Romantic Couples Psychological Science, 17 (10), 830-835 DOI: 10.1111/j.1467-9280.2006.01789.x

4 Alvergne, A., & Lummaa, V. (2010). Does the contraceptive pill alter mate choice in humans? Trends in Ecology & Evolution, 25 (3), 171-179 DOI: 10.1016/j.tree.2009.08.003

Sleep Less, Read More?

reading in bed?If you sleep for fewer than 6 hours a night and cannot get your hands on the latest John Grisham novel fast enough, you may not be alone.

According to recent research published in Reading Improvement, short-sleepers’ brains are insufficiently stimulated compared to long-sleepers’ brains, leading them to seek out stimuli such as reading and other cognitive activities that will make their neurons fire.

The study, conducted by Robert Morris University Associate Psychology Professor William E. Kelly, surveyed 223 college students about their sleeping and reading habits. Habitually short sleeping patterns were found to be highly correlated with higher reports of pleasure reading.

Read about a genetic mutation that could cause the difference between “short” and “long” sleepers.1

Read about a possible association between sleep duration and diabetes.

1 He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder JL Jr, Rossner MJ, Nishino S, & Fu YH (2009). The transcriptional repressor DEC2 regulates sleep length in mammals. Science (New York, N.Y.), 325 (5942), 866-70 PMID: 19679812

Programming DNA for Longevity

As the baby boomer generation approaches retirement and the “2030 problem” (i.e. caring for this doubling elderly population) looms large, increasing emphasis has been put upon research that will help people age more gracefully—and more gradually.

Scientists and doctors alike suggest that you can take control of your fate by drinking red wine and eating less. Exercise is also, obviously, key. Now, however, gene therapies (which don’t require work on your part) might be able to prevent aging, as well.

DNAScientists at the University of Washington found and began to tinker with a group of genes that turns on roundworms’ hypoxic response (the process by which cells continue to produce energy when deprived of oxygen—what brain cells do, for instance, in the case of a stroke). They discovered that if they altered the genes so that the response stayed constantly “on,” the worms lived longer, healthier lives. Lead researcher Matt Kaeberlin hypothesizes that the reaction may encourage cells’ glucose metabolization and assist stress resistance.

Read Kaeberlein’s latest research, published in Science, May 2009.1

Check out Kaeberlein’s ongoing research on his laboratory website.

1 Mehta, R., Steinkraus, K., Sutphin, G., Ramos, F., Shamieh, L., Huh, A., Davis, C., Chandler-Brown, D., & Kaeberlein, M. (2009). Proteasomal Regulation of the Hypoxic Response Modulates Aging in C. elegans Science, 324 (5931), 1196-1198 DOI: 10.1126/science.1173507

Advertisers are coming . . . with SOUND research

Billboards, magazines, banner ads—they all appeal to one sense: sight. In fact, according to author and marketing researcher Martin Lindstrom, 83% of all forms of advertising primarily appeals only to consumers’ sense of sight.

Plenty of neuromarketing research—in reputable journals such as Neuron1 and PNAS2—has studied this appeal: in response to visual ads, facial muscles flicker, pupils dilate, sweat glands excrete, and of course, the brain lights up. However, marketers might do well to broaden their sensual repertoire. Lindstrom has found that these same visually-induced emotive responses occur when subjects hear sounds, too.

Hearing

To measure physical responses, Lindstrom wired volunteers to monitoring devices while having them listen to a variety of sounds, ranging from popular Disney theme songs (e.g. “When You wish Upon a Star”) to birds chirping. The sound that elicited the most positive responses—in terms of self-rated “positive feelings” and involuntary measured responses—was a baby giggling. The runner-up was a vibrating cell phone.

The reason these sounds are so powerful is straightforward: consumers have had experiences that imbue the sounds with meaning; therefore, hearing the sounds triggers a corresponding reaction. (For example, you would become hungry if you hear a steak sizzling, thirsty if you hear a can of soda pop open.) Advertisers and retailers can take advantage of these ingrained reactions, and some already are:

  • The 0101 Japanese department store is matching certain soundscapes with departments, such as birdsongs and the perfume department, and lapping water and formalwear.

  • The British airport operator, BAA, increased sales in their Glasgow terminal by 10% by playing ambient sounds such as birdsong and crashing waves to create a more relaxed atmosphere where the customers did not feel the urge to “hurry up and buy.”

  • Some supermarkets may soon begin to play sounds of percolating coffee or fizzing soda near the beverage aisles in order to subtly encourage customers that they really want these items.

So listen up! Because you never know who might be making a play for your ears. . . .

1 Knutson, B., Rick, S., Wimmer, G., Prelec, D., & Loewenstein, G. (2007). Neural Predictors of Purchases Neuron, 53 (1), 147-156 DOI: 10.1016/j.neuron.2006.11.010

2 Plassmann, H., O’Doherty, J., Shiv, B., & Rangel, A. (2008). Marketing actions can modulate neural representations of experienced pleasantness Proceedings of the National Academy of Sciences, 105 (3), 1050-1054 DOI: 10.1073/pnas.0706929105

America’s Youth Overmedicated?

Is America’s youth overmedicated?

Child PillGiven that sales of behavioral drugs are growing faster than any other type of medicine taken by children—including antibiotics!—this might be a reasonable concern. An article from The Columbus Dispatch cites the use of medication as a “chemical restraint” for controlling mental illness. One hospital in Louisville, K.Y. was even caught administering drugs as “preventative measures” while children were asleep.

Author and journalist Judith Warner initially set out to validate all of these instances and compile her research in a book. However, as she pursued her subject matter, what she discovered changed her mind.

The product of her research, We’ve Got Issues: Children and Parents in the Age of Medication, reflects a viewpoint completely at odds with her initial beliefs. “Most children with mental health issues get no care at all,” she writes.

Some people agree; some people don’t.

Read a favorable book review in NY Times.

Read a critical book review in Slate magazine.

Gills: How Fish Avoid the “Pruney Fingers” Effect

Imagine if your lungs—instead of extracting O2 and expelling CO2—first sucked potassium, iron, and other essential nutrients directly out of the environment . . . and then got around to actually breathing. This would make you a lot more susceptible to that smog and acid rain we’ve been ignoring!

goldfishSimilarly, gills have always been assumed to be fish’s primary breathing organs. (Or at least since 1940, when the idea was suggested by Nobel Prize winner August Krogh.) However, recent research—including a study published in the January 2010 issue of Proceedings of the Royal Society B—suggests that fish first develop gills to exchange ions with their environment, not to breathe.1

Imagine emerging from a long bath: your fingers are usually shriveled and pruney. Fish avoid this effect by exchanging sodium and potassium with their environment. Simple fish that stay in static environments can perform this exchange through their skin, but when they start moving to habitats that can rapidly change salinity, fish need a more efficient mechanism for exchanging ions. Thus, they developed gills.

The Proceedings study, and others, raise concern over water pollution for this reason: if the primary reason that fish have gills is to exchange ions, and we block this exchange with pollution, are we drowning these fish? Or suffocating them. . . .

Read about the detrimental effects of pollution on freshwater Atlantic salmon.

Read an evaluation of how pollution affects rainbow trout as long ago as 1993!2

1 Fu, C., Wilson, J., Rombough, P., & Brauner, C. (2010). Ions first: Na+ uptake shifts from the skin to the gills before O2 uptake in developing rainbow trout, Oncorhynchus mykiss Proceedings of the Royal Society B: Biological Sciences DOI: 10.1098/rspb.2009.1545

2 Kirk, R., & Lewis, J. (1993). An evaluation of pollutant induced changes in the gills of rainbow trout using scanning electron microscopy Environmental Technology, 14 (6), 577-585 DOI: 10.1080/09593339309385326

Michael Lea: Moringa oleifera tree, low-cost water purification

Mindbogglingly useful: a new, low-cost water purification protocol for the developing world now freely available* to download from CP Microbiology:

Unit 1G.2 Bioremediation of Turbid Surface Water Using Seed Extract from Moringa oleifera Lam. (Drumstick) Tree

Moringa oleiferaIn the Hitch-hiker’s Guide to the Galaxy, Douglas Adams described his fictional creation, the all language-translating Babel fish, as being something ‘so mindbogglingly useful’ that it seemed almost inconceivable that it could have evolved by chance. This notion might equally apply to the drought-resistant Moringa oleifera tree, which can yield – among other things – cooking and lighting oil, soil fertilizer, as well as highly nutritious and tasty food in the form of its pods, leaves, seeds and flowers. In addition, as is set out in this unit published in Current Protocols in Microbiology, its seeds can be used as part of an inexpensive drinking water treatment technique that could help significantly reduce the incidence of waterborne disease in the developing world.

Around a billion people in parts of Asia, Africa, and Latin America rely on untreated surface water sources for their daily potable water needs. Of these, some 2 million are reckoned to die from waterborne diseases every year, the majority of these deaths being among children under 5 years of age. This amounts to a Mogadishu of fatalities every six months, and a Mexico City every decade. To help combat this appalling toll of avoidable mortality, Michael Lea* of Clearinghouse, an organization that researches and implements low- cost water purification technologies, has outlined a procedure that can reduce levels of harmful bacteria in water by around 90-99%, as well as reducing cloudiness, making the resulting drink aesthetically as well as microbiologically more acceptable for human consumption.

Water purification methods using seeds from the Moringa tree have been known about for centuries, but their use has been limited geographically. Cultivation of this tree as a food source is now spreading widely –amazingly the tree grows happily in all the regions where it can be most useful– but not many people know how to use the crushed seed powder as a coagulant to clean their water and potentially save lives. It is Lea’s hope that having the technique readily available via the internet from a reputable source in a protocol format – a first – will make dissemination to local community leaders, health workers and educational programs much easier.

The story doesn’t end there. This, after all, is the almost implausibly useful Moringa tree. Included with the protocol for purification is another that can be used for extracting a multi-purpose vegetable oil from the seeds, that leaves a ‘presscake’ that is just as effective in cleansing the water as the powder. Any surplus oil produced that is not needed for home cooking, lighting or mosquito repellent can then be sold, giving individuals a powerful economic incentive to use Moringa seeds over chlorine tablets—which are a daunting expense to people existing on small and uncertain incomes. Any surplus seed powder or presscake would also be saleable.

Michael Lea is at pains to stress that the use of these techniques will not be a panacea against waterborne disease. However, given that increasing the use of the Moringa tree can bring benefits in the shape of nutrition and income, as well as of purer water, there is the possibility that thousands of 21st century families could find themselves largely liberated from what should really be considered 19th century causes of death or debilitating disease. This prospect, and that of the human potential thereby released, is truly and happily mindboggling.

Made freely available as part of the John Wiley & Sons Corporate Citizenship Initiative.

A previous freely-available water treatment protocol authored by Michael Lea, Biological Sand Filters: Low-Cost Bioremediation Techniques for Production of Clean Drinking Water, is available here.

Hang Onto Your Tankard

BeersHistorically, wine has been lauded as the “healthy” alcoholic beverage. Per serving (4 oz glass) it contains about 30 fewer calories than the average 12 oz bottle of beer. The anti-aging compound reservatrol was recently discovered in red wine, along with other phytochemicals that can thin blood, improve cholesterol, and even reduce risk of cancer.

Yet, while beer has often followed in wine’s shadow, its virtues are now coming to light. Recent research suggests that drinking beer could actually help to prevent osteoporosis and cancer.

How?

University of California, Davis food science professor Charles Bamforth and graduate student Troy Davis published research this past February showing that beer is a rich source of silicon—a bone-strengthening nutrient 1. Previous research also shows that beer contains folate—a B vitamin that helps to prevent cancer and reduce birth defects 2.

So drinking a pint could prolong your life. Cheers to that!
-A. Goldstein

1 Casey, T., & Bamforth, C. (2010). Silicon in beer and brewing Journal of the Science of Food and Agriculture DOI: 10.1002/jsfa.3884

2 Mayer Jr, O., Šimon, J., & Rosolová, H. (2001). A population study of the influence of beer consumption on folate and homocysteine concentrations European Journal of Clinical Nutrition, 55 (7), 605-609 DOI: 10.1038/sj.ejcn.1601191

Driving Science Forward

BioBusStart with a 1974 San Francisco transit bus. Throw in some microscopes, computers, and digital cameras. Then, add a wind turbine, solar panels, and a grease-powered engine.

Final product? The Cell Motion Biobus!

This nearly-carbon-neutral “laboratory on wheels” was founded by Columbia University graduate Benjamin Dublin-Thaler in 2007. The mobile lab now putters around New York City and the Midwest, educating and inspiring a love of science in more than 10,000 students each year.

As one biology teacher put it, “If you spark the imagination of even five students, that’s worth it. It makes science real for them.”

  • Watch Dublin-Thaler speak about his project .
  • Follow the BioBus on its blog.
  • -A. Goldstein